Gene therapy has been more and more developed and considered as a promising approach in the treatment of both hereditary diseases and acquired diseases such as cancer, degenerative disorders and AIDS. However, few gene therapies have been translated into clinical application, because of degradation, non-specificity, and systematic toxicity. To overcome these issues, gene delivery nanosystems have been employed as promising candidates. Among many carriers, cationic liposome offers lots of distinct benefits, such as: simple preparation, good repeatability and biodegradability, the potential commercial value and wide range of clinical application and safety. In this project, we aim to fabricate a gene delivery nanosystem based on cationic liposome/nucleic acid complex combined with superparamagnetic iron oxide nanoparticles (SPION). This nanosystem can act as a theranostic system with both diagnostic and therapeutic effect. In vitro and in vivo studies will be carried out.
Thermosensitive ferromagnetic liposome for nucleic acid delivery
Institution : Université Paris Descartes
Promotion : 2017
Field of Study : Life and Health Sciences
Research Unit : Unité de Technologies Chimiques et Biologiques pour la santé
Doctoral School : Médicament, Toxicologie, Chimie et Imagerie (MTCI)
Thesis Description :