Marwah KARIM

Viruses, as an obligate intracellular pathogens depend on host cellular machineries to establish a successful infection and to propagate within host’s. The Ubiquitin Proteasome System (UPS), is central for regulating and maintain key cellular processes through post-translational modification of proteins. As such, the UPS is most frequently exploited by viruses, for their replication cycle as well as to evade host’s immune responses. In this project we are analyzing the interplay between host UPS and influenza A viruses (IAV) and study the mechanisms behind the rewiring of the UPS by IAV polymerase proteins.