Haotian GUO

Real-time probing in vivo RNA structure and interactions by RNA-based synthetic structure sensors 
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Unité de recherche : INSERM U1001
Description de la thèse :

RNA not only conveys the genetic information and but also performs as a key regulatory factor in the biological systems. Its function mostly relies on the structural characters and dynamics. We aim to develop a new methodology, using synthetic RNA system called “structure sensor” for real-time probing in vivo. The structure sensor is designed based on the RNA-RNA interaction, i.e. nucleic acid hybridization, consisting of a probe, a switch and a reporter.